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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
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The immune system needs 9.5 hours of sleep in total darkness to recharge completely.
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Though Candida and Aspergillus species are the most common fungal pathogens causing invasive fungal disease in the immunocompromised, infections due to previously uncommon hyaline and dematiaceous filamentous fungi are occurring more often today. Rare fungal infections, once accurately diagnosed, may require surgical debridement, immunotherapy, and newer antifungals used singly or in combination with older antifungals, on a case-by-case basis.
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In 1885, the Lloyd Manufacturing Company of Albany, New York, promoted and sold "Cocaine Toothache Drops" at 15 cents per bottle! In 1914, the Harrison Narcotic Act brought the sale and distribution of this drug under federal control.
The nitrogen cycle. Numbers represent fluxes as 1012 g N per year (data from Schlesinger 1991, after
Astronomers identified 12-billion-year-old white dwarf stars only 100 light years away from Earth
insect's compound eye, revealing photoreceptor cells, support cells and pigment cells
Grieving behavior can have common expressions in different cultures.
Serotonin and Risk-Taking Behavior
Wall Painting In The "Ixion Room," House of the Vettii