A person who has been diagnosed with HIV infection 12 years ago ...

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A person who has been diagnosed with HIV infection 12 years ago and still has a CD4+ cell count of 800 cells/ L and a low viral load is considered clinical to be a
 
  A)
  rapid progressor.
  B)
  typical progressor.
  C)
  slow progressor.
  D)
  long-term nonprogressor.

Question 2

A 4-year-old boy presents with a chronic cough and swollen lymph nodes. His records show that he has been given antibiotics several times in the past year with limited success,
 
  most recently for a liver abscess, and that he also has a recurring fungal skin condition. Which of the following is his most likely diagnosis?
  A)
  Selective IgA deficiency
  B)
  A deficiency in IgG2 subclass antibodies
  C)
  Chronic granulomatous disease
  D)
  Ataxia-telangiectasia

[chreslie]

Answer to Question 1

Ans:
D

Feedback:

There is a subset of slow progressors: the long-term nonprogressors, who account for 1 of all HIV infections. These people have been infected for at least 8 years, are antiretroviral naive, have high CD4+ cell counts, and usually have very low viral loads. They are being investigated to determine how they maintain viral suppression of HIV.

Answer to Question 2

Ans:
C

Feedback:

Chronic granulomatous disease, because it affects phagocytic function, increases susceptibility to soft tissue infections, particularly of the skin, lungs, lymph nodes, and liver. Selective IgA deficiency and deficient IgG2 subclass antibodies can predispose people to infection, but those infections respond readily to antibiotic treatment. Ataxia-telangiectasia can cause skin and liver problems, but its primary manifestations are ataxia and telangiectasia.

[skymedlock]

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