All of the following serine proteases are bound and inhibited by ...

[rayancarla1]

All of the following serine proteases are bound and inhibited by antithrombin except:
 
  a. Xa
  b. IXa
  c. VIIa
  d. XIa

Question 2

Why is the platelet count monitored daily for a patient receiving heparin therapeutically?
 
  a. Platelets increase when a patient is overheparinized.
  b. Platelets decrease when a patient is overheparinized.
  c. A significant decrease in the platelet count is evidence for heparin-induced thrombocytopenia.
  d. A significant increase in the platelet count is early evidence for heparin-induced thrombocytosis.

[dyrone]

Answer to Question 1

ANS: C
Antithrombin covalently binds and inhibits XIIa, XIa, Xa, IXa, and thrombin. It does not bind VIIa.

Answer to Question 2

ANS: C
A decrease of 40 or greater in the platelet count, even if the platelet count remains in the reference range, is evidence for heparin-induced thrombocytopenia. This is a serious consequence, and unfractionated heparin therapy must be immediately stopped and replaced with a direct thrombin inhibitor.

[rayancarla1]

YES! Correct, THANKS for helping me on my review

[kthug]

Thanks for the timely response, appreciate it