Author Question: Which of the following single-factor inherited deficiencies is most common as the cause for ... (Read 21 times)

cabate · **on:** Jun 25, 2018

Which of the following single-factor inherited deficiencies is most common as the cause for hemophilia?

a. Factor V
b. Factor VIII
c. Factor IX
d. Factor XI

Question 2

A 21-year-old woman has a primary complaint of menorrhagia. Her coagulation screen gives the following results. What disorder is most likely?

Test Result Reference range
Prothrombin time (PT) 12.0 seconds 11-15 seconds
Partial thromboplastin time (PTT) 40 seconds 25-37 seconds
Factor VIII activity 35 50-150
Platelet count 225 x 109/L 150-400 x 109/L

a. Hemophilia A
b. Hemophilia B
c. VWD, type 1
d. Factor X deficiency

snackralk · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

ANS: B
Eighty-five percent of congenital single-factor deficiencies are of factor VIII. This results in hemophilia A.

Answer to Question 2

ANS: C
VWD is the most prevalent of the congenital bleeding disorders, affecting both female and male subjects; hemophilia A and B both affect primarily male subjects. Female patients with VWD often complain of menorrhagia. Most patients with VWD have factor VIII levels in the range of 35 to 50.