Which of the following single-factor inherited deficiencies is ...

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Which of the following single-factor inherited deficiencies is most common as the cause for hemophilia?
 
  a. Factor V
  b. Factor VIII
  c. Factor IX
  d. Factor XI

Question 2

A 21-year-old woman has a primary complaint of menorrhagia. Her coagulation screen gives the following results. What disorder is most likely?
 
  Test Result Reference range
  Prothrombin time (PT) 12.0 seconds 11-15 seconds
  Partial thromboplastin time (PTT) 40 seconds 25-37 seconds
  Factor VIII activity 35 50-150
  Platelet count 225 x 109/L 150-400 x 109/L
 
  a. Hemophilia A
  b. Hemophilia B
  c. VWD, type 1
  d. Factor X deficiency

[snackralk]

Answer to Question 1

ANS: B
Eighty-five percent of congenital single-factor deficiencies are of factor VIII. This results in hemophilia A.

Answer to Question 2

ANS: C
VWD is the most prevalent of the congenital bleeding disorders, affecting both female and male subjects; hemophilia A and B both affect primarily male subjects. Female patients with VWD often complain of menorrhagia. Most patients with VWD have factor VIII levels in the range of 35 to 50.

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TYSM

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Excellent