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Author Question: What protein does heparin work with to inhibit coagulation? a. Protein S b. Antithrombin c. ... (Read 46 times)

K@

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on: Jun 25, 2018
What protein does heparin work with to inhibit coagulation?
 
  a. Protein S
  b. Antithrombin
  c. Vitamin K
  d. Factor VII

Question 2

What is the role of the thrombin-thrombomodulin complex?
 
  a. Initiates vasoconstriction
  b. Activates thrombin
  c. Inhibits factor Xa
  d. Activates protein C


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mcabuhat

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Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: B
Heparin binds to antithrombin, thus bringing thrombin in close proximity to antithrombin. It also changes the configuration of antithrombin so that it can effectively bind thrombin. The thrombin-antithrombin complex renders thrombin inactive; the complex is taken to the liver and cleared.

Answer to Question 2

ANS: D
Thrombin binds the endothelial cell membrane protein thrombomodulin, and the complex then activates protein C. Activated protein C complexes with protein S, and the complex degrades factors Va and VIIIa, which downregulates thrombin generation.


K@

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Reply 2 on: Jun 25, 2018
Thanks for the timely response, appreciate it

pratush dev

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Reply 3 on: Yesterday
Excellent

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