Author Question: A 27-year-old woman arrives at the emergency department with acute bleeding and is found to have a ... (Read 33 times)

Lobcity · **on:** Jun 25, 2018

A 27-year-old woman arrives at the emergency department with acute bleeding and is found to have a white count of 25.7 x 109L with pancytopenia: hematocrit 27, platelet count 35 x 109/L, and absolute neutrophil count 0.8 x 109/L.

She has a combination of 97 blasts and abnormal promyelocytes in her peripheral blood; some of these cells contain stacked Auer rods. What form of leukemia does she most likely have?

a. Acute myeloid leukemia with t(15;17)(q22:q12)
b. Chronic myeloid leukemia
c. Acute monoblastic leukemia
d. Acute myeloid leukemia with t(8;21)(q33:q22)

Question 2

Acute myelomonocytic leukemia is positive for which of the following?

a. CALLa (CD10)
b. Periodic acidSchiff (PAS)
c. HLA-DR1a
d. CD13 and CD14

mfedorka · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

ANS: A
Acute myeloid leukemia with t(15;17)(q22:q12) is characterized by abnormal promyelocytes, which may have stacked Auer rods. Patients are most often young adults. When bundles of Auer rods are found in a cell, they are called faggot cells.

Answer to Question 2

ANS: D
The cells in acute myelomonocytic leukemia are positive for CD13 (a myeloid antigen) and CD14 (a monocytic antigen).