A 15-year-old boy is complaining of severe headaches; he has a ...

[bobthebuilder]

A 15-year-old boy is complaining of severe headaches; he has a white count of 76.0 x 109/L, platelet count of 55 x 109/L, and a hematocrit of 33.
 
  When a white cell differential is performed, most of the nucleated cells are blasts. They are CD2, CD4, and CD8 positive. What is the most likely diagnosis?
 
  a. Immature-B cell acute lymphoblastic leukemia
  b. T-cell acute lymphoblastic leukemia
  c. Acute myeloid leukemia without maturation
  d. Acute myeloid leukemia with maturation

Question 2

Which form of acute myeloid leukemia is most often associated with disseminated intravascular coagulation (DIC)?
 
  a. Acute myeloid leukemia minimally differentiated
  b. Acute myeloid leukemia with t(8;21)(q33:q22)
  c. Acute myeloid leukemia with t(15;17)(q22:q12)
  d. Acute myeloid leukemia with maturation

[Loise Hard]

Answer to Question 1

ANS: B
T-cell acute lymphoblastic leukemia is most often seen in teenage boys with a mediastinal mass, elevated peripheral blast counts, meningeal involvement, and infiltration of extra marrow sites. The blasts commonly mark as CD2, CD4, CD5, and CD8 positive.

Answer to Question 2

ANS: C
Acute myeloid leukemia with t(8;21)(q22:q12), also known as acute promyelocytic leukemia, is associated with DIC. Treatment of this disorder must therefore involve resolution of the DIC.