Author Question: What do all chronic myeloproliferative disorders share? a. Philadelphia chromosome b. Increased ... (Read 78 times)

Marty · **on:** Jun 25, 2018

What do all chronic myeloproliferative disorders share?

a. Philadelphia chromosome
b. Increased red cell mass
c. Increased blood cells; overlapping clinical and laboratory features
d. Serious thromboembolic complications

Question 2

Which of the following would be an unexpected finding in chronic myelogenous leukemia?

a. Increased eosinophils (EOs) and basophils in the peripheral blood
b. 20 Blasts in the peripheral blood
c. Hypercellular bone marrow with granulopoiesis
d. White blood count of 100 109/L

rnehls · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

ANS: C
The chronic myeloproliferative disorders all have increased blood cells, although which one (or ones) varies depending on the condition. They also all have overlapping clinical features. The Philadelphia chromosome is only found in chronic myelogenous leukemia within this classification. Polycythemia vera uniquely has an increased red cell mass, and serious thromboembolic complications are primarily seen in essential thrombocythemia, although they also can be a complication of polycythemia vera when the patient is treated with phlebotomy only.

Answer to Question 2

ANS: B
Myeloblasts plus promyelocytes are usually present between 1 and 5 in chronic myelogenous leukemia. A total of 20 blasts plus promyelocytes is proposed for the classification of chronic myelogenous leukemia accelerated phase. All the other findings listed are characteristic of chronic myelogenous leukemia.