Which chronic myeloproliferative disorder is treated with ...

[pragya sharda]

Which chronic myeloproliferative disorder is treated with Imatinib mesylate (Gleevec), a drug that inhibits tyrosine kinase?
 
  a. Polycythemia vera
  b. Chronic myelogenous leukemia
  c. Essential thrombocythemia
  d. Primary myelofibrosis

Question 2

Chronic myelogenous leukemia often progresses to:
 
  a. Chronic neutrophilic leukemia
  b. Chronic lymphocytic leukemia
  c. Acute leukemia, either myeloid or lymphoblastic
  d. Chronic idiopathic myelofibrosis

[mochi09]

Answer to Question 1

ANS: B
Chronic myelogenous leukemia is effectively treated with Imatinib mesylate. This drug inhibits most of the transforming capability stemming from the tyrosine kinase (P210) activity of the bcr/abl fusion gene. This P210 fusion protein is not found in the other myeloproliferative disorders, so the drug is ineffective in these disorders.

Answer to Question 2

ANS: C
Chronic myelogenous leukemia often progresses to acute leukemia, which may be either myeloid or lymphoblastic.

[pragya sharda]

Thanks for the timely response, appreciate it

[CAPTAINAMERICA]

Excellent