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Author Question: Which chronic myeloproliferative disorder is treated with Imatinib mesylate (Gleevec), a drug that ... (Read 24 times)

pragya sharda

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on: Jun 25, 2018
Which chronic myeloproliferative disorder is treated with Imatinib mesylate (Gleevec), a drug that inhibits tyrosine kinase?
 
  a. Polycythemia vera
  b. Chronic myelogenous leukemia
  c. Essential thrombocythemia
  d. Primary myelofibrosis

Question 2

Chronic myelogenous leukemia often progresses to:
 
  a. Chronic neutrophilic leukemia
  b. Chronic lymphocytic leukemia
  c. Acute leukemia, either myeloid or lymphoblastic
  d. Chronic idiopathic myelofibrosis


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mochi09

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Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: B
Chronic myelogenous leukemia is effectively treated with Imatinib mesylate. This drug inhibits most of the transforming capability stemming from the tyrosine kinase (P210) activity of the bcr/abl fusion gene. This P210 fusion protein is not found in the other myeloproliferative disorders, so the drug is ineffective in these disorders.

Answer to Question 2

ANS: C
Chronic myelogenous leukemia often progresses to acute leukemia, which may be either myeloid or lymphoblastic.


pragya sharda

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Reply 2 on: Jun 25, 2018
Thanks for the timely response, appreciate it

mcabuhat

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Reply 3 on: Yesterday
Excellent

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