« previous next »

Author Question: A patient has a leukocyte alkaline phosphatase score of 9. The positive control is 5. Select the ... (Read 55 times)

lb_gilbert

  • Hero Member
  • *****
  • Posts: 588
on: Jun 25, 2018
A patient has a leukocyte alkaline phosphatase score of 9. The positive control is 5. Select the correct interpretation.
 
  a. Chronic myelogenous leukemia
  b. Acute lymphocytic leukemia
  c. Polycythemia vera
  d. Test must be repeated

Question 2

A myeloperoxidase stain is performed on peripheral blood cells of a patient with acute leukemia and 85 blasts; the patient has an occasional mature neutrophil.
 
  When the stained slide is evaluated, the blasts are all negative but the mature neutrophils are strongly positive. What is the significance of this finding?
 
  a. The stain worked (internal positive control).
  b. Nothing can be determined until a positive control is also examined.
  c. Nothing can be determined because mature neutrophils are always positive.
  d. Nothing can be determined because only examination of the blasts is useful.


Dominic

  • Sr. Member
  • ****
  • Posts: 328
Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: D
Positive controls should always be run with any cytochemical stain to assure that the stain worked. The positive control in this case is essentially negative (score of 5), so the stain must be repeated.

Answer to Question 2

ANS: A
The finding of positive neutrophils on the slide serves as an internal quality control to validate that the stain worked. If only blasts had been present (no mature neutrophils), and they were all negative, it would be crucial to examine the positive control stained at the same time before a negative result in the blasts would be significant. Proof that the staining was successful must exist before any result on blasts has meaning.


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
« previous next »
 

Did you know?

Allergies play a major part in the health of children. The most prevalent childhood allergies are milk, egg, soy, wheat, peanuts, tree nuts, and seafood.

Did you know?

Earwax has antimicrobial properties that reduce the viability of bacteria and fungus in the human ear.

Did you know?

The strongest synthetic topical retinoid drug available, tazarotene, is used to treat sun-damaged skin, acne, and psoriasis.

Did you know?

Amoebae are the simplest type of protozoans, and are characterized by a feeding and dividing trophozoite stage that moves by temporary extensions called pseudopodia or false feet.

Did you know?

Stevens-Johnson syndrome and Toxic Epidermal Necrolysis syndrome are life-threatening reactions that can result in death. Complications include permanent blindness, dry-eye syndrome, lung damage, photophobia, asthma, chronic obstructive pulmonary disease, permanent loss of nail beds, scarring of mucous membranes, arthritis, and chronic fatigue syndrome. Many patients' pores scar shut, causing them to retain heat.

A hearing-impaired patient using an interpreter. A hearing-impaired patient using an interpreter.
EHR systems enable providers to view patient records across organizations. EHR systems enable providers to view patient records across organizations.
Head of a patient with tertiary syphilis. Head of a patient with tertiary syphilis.
Select the changes in the embryo that indicate that a blastocyst has formed. 3 options: t Select the changes in the embryo that indicate that a blastocyst has formed. 3 options: t
Antisense RNA control of the expression of IS10 transposase Antisense RNA control of the expression of IS10 transposase
Video: Dendrite Animation

For a complete list of videos, visit our video library