Compare results of various tests in effective versus ineffective ...

[mwit1967]

Compare results of various tests in effective versus ineffective erythropoiesis.
 
  a. Both have increased rate of erythropoiesis in the bone marrow.
  b. Both have an elevated reticulocyte production index (RPI) greater than 3.
  c. Both have normal release of RBCs from the bone marrow.
  d. Both have significantly shortened red cell survival in circulation.

Question 2

Which of the following is true of ineffective erythropoiesis?
 
  a. Lymphopenia and anemia are present.
  b. RBC production in bone marrow is increased.
  c. Release of RBCs to the peripheral blood is normal.
  d. RBC survival in circulation is less than 40 days.

[Anonymous]

Answer to Question 1

ANS: A
In both effective and ineffective erythropoiesis, the rate of red cell production in the bone marrow is increased (increased erythropoiesis). However, release to circulation differs in the two: it is successful in effective, but not in ineffective where significant intramedullary loss occurs. Thus the RPI is greater than 3 in effective, but usually less than 2 in ineffective. Red cell survival in circulation is significantly decreased in effective, but essentially normal or insignificantly shortened in ineffective.

Answer to Question 2

ANS: B
RBC production in the bone marrow is increased in ineffective erythropoiesis (decreased M:E ratio). However, production is defective, and many of the red cells are destroyed before leaving the marrow. Thus release of RBCs to peripheral blood is decreased. Although survival of these RBCs in circulation may be slightly shortened from the normal of 120 days, it is not significant (the increased rate of production in the marrow could fully compensate for the slight shortening if the red cells were all released to circulation). Lymphopenia is not characteristic of these anemias.

[mwit1967]

Thanks for the timely response, appreciate it

[juliaf]

Excellent