Author Question: What is the earliest morphologically identifiable cell in the granulocyte maturation sequence? a. ... (Read 71 times)

joesmith1212 · **on:** Jun 25, 2018

What is the earliest morphologically identifiable cell in the granulocyte maturation sequence?

a. Pluripotent stem cell
b. Colony-forming unitgranulocyte, erythrocyte, monocyte, and megakaryocyte (CFU-GEMM)
c. Myeloblast
d. Myelocyte

Question 2

What pools of leukocytes are included in the typical white blood count?

a. All cells inside the blood vessel
b. Only cells freely circulating
c. Only cells marginating against the vessel wall
d. All leukocytes in the body

cswans24 · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

ANS: C
The earliest cell that can be identified by morphology, using Wright stain, as belonging to the granulocyte maturation sequence is the myeloblast. The pluripotent stem cell and the CFU-GEMM are identified by various receptors present on the cell membrane using monoclonal antibodies and flow cytometric techniques. The myelocyte is a later stage of development than the myeloblast.

Answer to Question 2

ANS: B
The clinician performs the white blood cell (WBC) count by counting the number of white cells in blood. However, a pool of granulocytes exists that is marginated (clinging to the sides of small blood vessels). Even though they are still in the blood vessel, these granulocytes are not freely circulating and are not counted. Only freely circulating white cells of all types are counted.