Explain the effects of the following on coagulation testing: ...

[xroflmao]

Explain the effects of the following on coagulation testing:
 
  a. Clotted sample
  b. Ratio of blood to anticoagulant < 9:1
  c. Patient hematocrit >55
  d. >1-hour difference between specimen collection and analysis
 
  What will be an ideal response?

Question 2

According to the International Society on Thrombosis (ISTH), the guidelines for diagnostic criteria for LA/aPL include the demonstration of which of the following?
 
  a. Normal phospholipid-dependent coagulation reaction
  b. Absence of a clotting factor
  c. Presence of an inhibitor
  d. Abnormal PT

[adf223]

Answer to Question 1

Answer:
Clotted sample: Because factors are consumed in the formation of the clot in the tube, they will be unavailable to form a clot in vitro. The result will be a prolonged time with the coagulation tests.
Ratio of blood to anticoagulant <9:1: there will be too much anticoagulant for the amount of plasma present. this cause specimen to over-anticoagulated and thus a prolongation in clot-based assay times.
Patient hematocrit >55: The proportion of cells to plasma will not be optimal for the amount of anticoagulant present in the tube, resulting in the same scenario as in b.
>1-hour difference between specimen collection and analysis: Depending on the length of time elapsed between specimen collection and analysis, a delay in processing and testing the sample can cause the labile factors in the sample to degrade and prolong clotting times.

Answer to Question 2

Correct Answer: C

[xroflmao]

Correct answers!

[adf223]

Great! Please up vote