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Author Question: Explain the effects of the following on coagulation testing: a. Clotted sample b. Ratio of blood ... (Read 129 times)

xroflmao

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on: Jun 25, 2018
Explain the effects of the following on coagulation testing:
 
  a. Clotted sample
  b. Ratio of blood to anticoagulant < 9:1
  c. Patient hematocrit >55
  d. >1-hour difference between specimen collection and analysis
 
  What will be an ideal response?

Question 2

According to the International Society on Thrombosis (ISTH), the guidelines for diagnostic criteria for LA/aPL include the demonstration of which of the following?
 
  a. Normal phospholipid-dependent coagulation reaction
  b. Absence of a clotting factor
  c. Presence of an inhibitor
  d. Abnormal PT


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adf223

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer:
Clotted sample: Because factors are consumed in the formation of the clot in the tube, they will be unavailable to form a clot in vitro. The result will be a prolonged time with the coagulation tests.
Ratio of blood to anticoagulant <9:1: there will be too much anticoagulant for the amount of plasma present. this cause specimen to over-anticoagulated and thus a prolongation in clot-based assay times.
Patient hematocrit >55: The proportion of cells to plasma will not be optimal for the amount of anticoagulant present in the tube, resulting in the same scenario as in b.
>1-hour difference between specimen collection and analysis: Depending on the length of time elapsed between specimen collection and analysis, a delay in processing and testing the sample can cause the labile factors in the sample to degrade and prolong clotting times.

Answer to Question 2

Correct Answer: C


xroflmao

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Reply #2 on: Jun 25, 2018
Correct answers!


adf223

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Reply #3 on: Jun 25, 2018
Great! Please up vote :D


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