Name the genetic mutation that induces increased concentration of prothrombin in the circulation that leads to increased risk of venous thrombosis.
a. G A substitution on nucleotide 20210 of the prothrombin gene
b. Lysine to glutamic acid substitution on the sixth position on the beta globin chain
c. Arginine to glutamine substitution at the 506 position of prothrombin
d. Translocation of chromosome 22 onto the long arm of chromosome 9
Question 2
Why does a patient who had a thrombotic incident receive both heparin and Coumadin for 4-5 days before heparin is discontinued?
a. Heparin is not effective as an anticoagulant without Coumadin.
b. Coumadin requires heparin for its full anticoagulant effect.
c. Coumadin and heparin have a synergistic effect
d. Coumadin 's full effect is not achieved for 4- days after initiation because of the half-life of the vitamin K coagulation factors.
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