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Author Question: What laboratory tests typically are utilized to detect lupus anticoagulants? What will be an ... (Read 82 times)

storky111

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on: Jun 25, 2018
What laboratory tests typically are utilized to detect lupus anticoagulants?
 
  What will be an ideal response?

Question 2

Patients with a DVT are at risk for developing which of the following?
 
  a. Transient ischemic attacks
  b. Peripheral artery disease
  c. Myocardial infarction
  d. Pulmonary emboli


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abctaiwan

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer:
The tests are:
 APTT (screen) the majority of LAs are detected beginning with a prolonged APTT.
 DRVVT  dilute Russell viper venom time. Utilizes snake venom to initiate factor X cleavage independently from standard in vitro measurements. Used to rule out heparin involvement that results in a prolonged APTT.
 Mixing study  increasing dilutions of patient plasma with normal pooled plasma (NPP) are mixed together, and an APTT is measured. If an inhibitor is present in the patient's plasma, it will inhibit not only the phospholipid in the patient plasma but also the phospholipid in the NPP and thereby cause a minimal correction with increasing dilutions.
 Modified mixing study with the addition of phospholipid  the addition of phospholipid will neutralize the LA and thus cause a shortening of the time. This will confirm an LA.

Answer to Question 2

Correct Answer: D


storky111

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Reply 2 on: Jun 25, 2018
Great answer, keep it coming :)

aliotak

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Reply 3 on: Yesterday
Thanks for the timely response, appreciate it

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