This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Beginning with the trauma, what is the sequence of events that leads to the formation of a clot ... (Read 80 times)

nenivikky

  • Hero Member
  • *****
  • Posts: 516
on: Jun 25, 2018
Beginning with the trauma, what is the sequence of events that leads to the formation of a clot (thrombus)? .
 
  What will be an ideal response?

Question 2

Correlate blood vessel histology to vessel type and function in hemostasis.
 
  What will be an ideal response?


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

jlaineee

  • Sr. Member
  • ****
  • Posts: 380
Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer:
1. Trauma occurs.
2. Subendothelial collagen is exposed.
3. Vasoconstriction is initiated to minimize blood loss.
4. Platelets become activated as a result of the subendothelial collagen  (a) flat, discoid shape  spiked appearance, (b) actin and myosin go from a random arrangement to a parallel arrangement; (c) tubulin forms a circumferential band around the organelle zone to assist in expelling granular contents to the surface of the platelets.
5. Activated platelets adhere to subendothelial collagen with the help of VWF and GP Ib/IX.
6. Once adhesion takes place, more platelets are recruited to the site, and aggregation is initiated. Substances needed for platelet aggregation is fibrinogen and GP IIb/IIIa.
7. Platelets secrete their granular contents and initiate secondary hemostasis.
8. Secondary hemostasis is activated by contact activation and subsequent progression into the coagulation cascade via the intrinsic and extrinsic pathways.
9. The end result is the formation of an insoluble fibrin polymer that stabilizes the platelet plug.
10. Fibroblasts grow and regenerate with the help of PDGF and other tissue repair chemokines.
11. Once repair is completed, the fibrinolysis pathway is activated.
12. Fibrin and tPA induce activation of plasmin from plasminogen.
13. Plasmin chemically digests the fibrin polymer into measurable fragments that can be detected in vitro.
14. Normal homeostasis is restored.

Answer to Question 2

Answer: Tunica adventitia: thick outer layer of the blood vessels responsible for maintaining blood pressure; is thicker in veins than in arteries
Tunica media: middle layer responsible for vasoconstriction and vasodilation; is thicker in arteries than in veins
Tunica intima: has direct interaction with peripheral blood constituents; all three types of vessels (arteries, veins, and capillaries) in close tunica intima layers


nenivikky

  • Member
  • Posts: 516
Reply 2 on: Jun 25, 2018
Excellent

daiying98

  • Member
  • Posts: 354
Reply 3 on: Yesterday
:D TYSM

« previous next »
 

Did you know?

Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.

Did you know?

Drug abusers experience the following scenario: The pleasure given by their drug (or drugs) of choice is so strong that it is difficult to eradicate even after years of staying away from the substances involved. Certain triggers may cause a drug abuser to relapse. Research shows that long-term drug abuse results in significant changes in brain function that persist long after an individual stops using drugs. It is most important to realize that the same is true of not just illegal substances but alcohol and tobacco as well.

Did you know?

The Centers for Disease Control and Prevention (CDC) was originally known as the Communicable Disease Center, which was formed to fight malaria. It was originally headquartered in Atlanta, Georgia, since the Southern states faced the worst threat from malaria.

Did you know?

Drying your hands with a paper towel will reduce the bacterial count on your hands by 45–60%.

Did you know?

The largest baby ever born weighed more than 23 pounds but died just 11 hours after his birth in 1879. The largest surviving baby was born in October 2009 in Sumatra, Indonesia, and weighed an astounding 19.2 pounds at birth.

An electrocardiogram (EKG) wave, a record of the electrical signal as it moves through the conductio An electrocardiogram (EKG) wave, a record of the electrical signal as it moves through the conductio
The Hippocampal Formation and Long-Term Potentiation The Hippocampal Formation and Long-Term Potentiation
Major Events in the History of Psychology Major Events in the History of Psychology
Hector makes payments of $2000.00 into an RRSP at the beginning of every six months starting ... Hector makes payments of $2000.00 into an RRSP at the beginning of every six months starting ...
Inadequate Airway, Breathing and Circulation in the Trauma Patient (Part 2) Inadequate Airway, Breathing and Circulation in the Trauma Patient (Part 2)
Vascular events in the acute inflammatory process Vascular events in the acute inflammatory process
Video: Plant Defense Mechanisms from Pathogens

For a complete list of videos, visit our video library