This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Beginning with the trauma, what is the sequence of events that leads to the formation of a clot ... (Read 30 times)

nenivikky

  • Hero Member
  • *****
  • Posts: 516
on: Jun 25, 2018
Beginning with the trauma, what is the sequence of events that leads to the formation of a clot (thrombus)? .
 
  What will be an ideal response?

Question 2

Correlate blood vessel histology to vessel type and function in hemostasis.
 
  What will be an ideal response?


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

jlaineee

  • Sr. Member
  • ****
  • Posts: 380
Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer:
1. Trauma occurs.
2. Subendothelial collagen is exposed.
3. Vasoconstriction is initiated to minimize blood loss.
4. Platelets become activated as a result of the subendothelial collagen  (a) flat, discoid shape  spiked appearance, (b) actin and myosin go from a random arrangement to a parallel arrangement; (c) tubulin forms a circumferential band around the organelle zone to assist in expelling granular contents to the surface of the platelets.
5. Activated platelets adhere to subendothelial collagen with the help of VWF and GP Ib/IX.
6. Once adhesion takes place, more platelets are recruited to the site, and aggregation is initiated. Substances needed for platelet aggregation is fibrinogen and GP IIb/IIIa.
7. Platelets secrete their granular contents and initiate secondary hemostasis.
8. Secondary hemostasis is activated by contact activation and subsequent progression into the coagulation cascade via the intrinsic and extrinsic pathways.
9. The end result is the formation of an insoluble fibrin polymer that stabilizes the platelet plug.
10. Fibroblasts grow and regenerate with the help of PDGF and other tissue repair chemokines.
11. Once repair is completed, the fibrinolysis pathway is activated.
12. Fibrin and tPA induce activation of plasmin from plasminogen.
13. Plasmin chemically digests the fibrin polymer into measurable fragments that can be detected in vitro.
14. Normal homeostasis is restored.

Answer to Question 2

Answer: Tunica adventitia: thick outer layer of the blood vessels responsible for maintaining blood pressure; is thicker in veins than in arteries
Tunica media: middle layer responsible for vasoconstriction and vasodilation; is thicker in arteries than in veins
Tunica intima: has direct interaction with peripheral blood constituents; all three types of vessels (arteries, veins, and capillaries) in close tunica intima layers


nenivikky

  • Member
  • Posts: 516
Reply 2 on: Jun 25, 2018
Gracias!

rachel

  • Member
  • Posts: 323
Reply 3 on: Yesterday
YES! Correct, THANKS for helping me on my review

« previous next »
 

Did you know?

When Gabriel Fahrenheit invented the first mercury thermometer, he called "zero degrees" the lowest temperature he was able to attain with a mixture of ice and salt. For the upper point of his scale, he used 96°, which he measured as normal human body temperature (we know it to be 98.6° today because of more accurate thermometers).

Did you know?

Approximately 70% of expectant mothers report experiencing some symptoms of morning sickness during the first trimester of pregnancy.

Did you know?

Computer programs are available that crosscheck a new drug's possible trade name with all other trade names currently available. These programs detect dangerous similarities between names and alert the manufacturer of the drug.

Did you know?

Cyanide works by making the human body unable to use oxygen.

Did you know?

Hip fractures are the most serious consequences of osteoporosis. The incidence of hip fractures increases with each decade among patients in their 60s to patients in their 90s for both women and men of all populations. Men and women older than 80 years of age show the highest incidence of hip fractures.

The formation of a chimeric gene that is found in people with certain forms of leukemia. The formation of a chimeric gene that is found in people with certain forms of leukemia.
FORMATION OF WBC AND RBC FORMATION OF WBC AND RBC
Sequence of patient positions for heart auscultation Sequence of patient positions for heart auscultation
Major Events in the History of Psychology (6 of 6) Major Events in the History of Psychology (6 of 6)
Annotation of a DNA sequence containing part of the human globin gene Annotation of a DNA sequence containing part of the human globin gene
The formation of cAMP from ATP, catalyzed by adenyl cyclase The formation of cAMP from ATP, catalyzed by adenyl cyclase
Video: What Are Carbohydrates? Importance of Carbs & High Carb Food

For a complete list of videos, visit our video library