Author Question: Which of the following describes how platelet clumping artificially alters platelet parameters? ... (Read 31 times)

sjones · **on:** Jun 25, 2018

Which of the following describes how platelet clumping artificially alters platelet parameters?

a. Increases both the PDW and the MPV
b. Decreases both the PDW and the MPV
c. Increases the PDW and decreases the MPV
d. Decreases the PDW and increases the MPV

Question 2

Identify the major cytokines that regulate platelet production and describe their effects on megakaryocytic cells and circulating platelets.

What will be an ideal response?

amy.lauersdorf90 · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

Correct Answer: A

Answer to Question 2

Answer: All stages of megakaryocyte development are influenced by TPO including megakaryocyte survival, proliferation, the ploidy level, and the rate of maturation. Stromal cell-derived factor-1 (SDF-1) augments TPO-induced megakaryocyte growth and endothelial adhesion within the marrow microenvironment. TPO also regulates the number of platelets in the peripheral blood. TPO binds to the c-Mpl receptor on platelets in circulation, is internalized, and is degraded to regulate the amount of TPO that can influence platelet progenitors.
Megakaryocyte progenitors proliferate in the presence of IL-3, GM-CSF, stem cell factor, and Flt ligand, whereas megakaryocyte maturation is influenced by IL-6 and
IL-7 (with other cytokines). Transforming growth factor- (TGF-) and -interferon (IFN-) both inhibit megakaryopoiesis.