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Author Question: Explain the role of epigenetic alterations in cancer development. What will be an ideal ... (Read 54 times)

gbarreiro

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on: Jun 25, 2018
Explain the role of epigenetic alterations in cancer development.
 
  What will be an ideal response?

Question 2

Predict the effect that the Bax:Bcl-2 complex will have on the apoptotic pathway.
 
  a. The pathway is activated by Bax: Bcl-2.
  b. The pathway is inhibited by Bax: Bcl-2.
  c. The pathway is not affected by Bax: Bcl-2.
  d. The pathway is activated and then is inhibited by Bax:Bcl-2.


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nikmaaacs

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer: The most common epigenetic change in the development of cancer involves a methylation/demethylation of CpG dinucleotide bases. Cancer can involve demethylation of promoter regions of genes making them transcriptionally ready. Methylation can result in transcriptional silencing of the gene and loss of function of tumor suppressor genes. Deacetylation of key histones can result in gene silencing which may favor growth over differentiation.

Answer to Question 2

Correct answer: B


gbarreiro

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Reply 2 on: Jun 25, 2018
Great answer, keep it coming :)

bblaney

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Reply 3 on: Yesterday
Wow, this really help

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