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The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.
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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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Women are 50% to 75% more likely than men to experience an adverse drug reaction.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.