From the list below, identify causes of delayed or dysfunctional ...

[123654777]

From the list below, identify causes of delayed or dysfunctional wound healing. Select all that apply.
 
  1. Predisposing chronic condition, such as diabetes
   2. Hypoxemia
   3. Hypervolemia
   4. Overweight or obesity
   5. Prolonged infection
   6. Corticosteroid therapy

Question 2

Which of the following is characteristic of the inflammation phase of wound healing?
 
  1. Wound contraction and inward movement of the wound edge
   2. Clot formation to seal the wound
   3. Decreased blood flow and capillary permeability, causing swelling
   4. Regeneration of destroyed cells

[pocatato]

Answer to Question 1

1, 2, 5, 6
Rationale:
1. Conditions such as diabetes affect circulating blood volume, and are known to affect healing.
2. Hypoxemia makes tissues susceptible to infection due to insufficient oxygenation.
3. Hypovolemia, not hypervolemia, would inhibit inflammation due to low circulating blood volume.
4. Overweight and obesity themselves might not affect wound healing. However, poor nutrition without proper protein and calorie intake will affect healing.
5. Prolonged infection can affect healing and cause excessive scarring.
6. Corticosteroid therapy or other immunocompromising therapy will prevent macrophages from migrating to the site of injury, and suppress epithelialization.

Answer to Question 2

2
Rationale:
1. Wound contraction and inward movement of the wound edge occur during the reconstruction phase of wound healing.
2. Clot formation to seal the wound with fibrin and trapped cells and platelets occurs during the inflammation phase of wound healing, in the first 35 days.
3. Increased blood flow to the area and increased capillary permeability occur, causing swelling and inflammation.
4. Regeneration of destroyed cells occurs in the reconstruction phase of wound healing.

[123654777]

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