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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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The most destructive flu epidemic of all times in recorded history occurred in 1918, with approximately 20 million deaths worldwide.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.