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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
There are approximately 3 million unintended pregnancies in the United States each year.
Normal urine is sterile. It contains fluids, salts, and waste products. It is free of bacteria, viruses, and fungi.
In the United States, an estimated 50 million unnecessary antibiotics are prescribed for viral respiratory infections.
More than nineteen million Americans carry the factor V gene that causes blood clots, pulmonary embolism, and heart disease.