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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.
It is difficult to obtain enough calcium without consuming milk or other dairy foods.
Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.