Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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Nearly 31 million adults in America have a total cholesterol level that is more than 240 mg per dL.
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