A patient is taking sertraline (Zoloft). Because of the danger of ...

[waynest]

A patient is taking sertraline (Zoloft). Because of the danger of toxicity, the nurse advises the patient to avoid which food?
 
  1. Milk
  2. Peanuts
  3. Grapefruit
  4. Orange juice

Question 2

What reactions to medications are influenced by chemical biotransformations in the liver's enzymatic pathways? Select all that apply.
 
  1. Tolerance
  2. Toxicity
  3. Potency
  4. Resistance
  5. Therapeutic range

[reversalruiz]

Answer to Question 1

Answer: 3
Explanation: Grapefruit is an inhibitor of CYP450-3A4, which affects the metabolism of a sertraline (Zoloft), which could potentially build up to toxic levels. Although certain individuals may be sensitive to peanuts or dairy products, these foods have not been associated with increasing the toxicity of Zoloft. Orange juice may be taken as a citrus alternative to grapefruit juice.

Answer to Question 2

Answer: 1, 2, 4
Explanation: An enzyme system in the liver facilitates chemical biotransformations. Reactions in these enzymatic pathways contribute to drug resistance, drug tolerance, and drug toxicity. The amount (dose) of the drug necessary to produce the desired response is its potency. The therapeutic range is the range at which therapeutic efficacy can be achieved without risking harm to the patient.