What factors influence the metabolic liver enzymes contained in ...

[karen]

What factors influence the metabolic liver enzymes contained in the cytochrome P450 system?
 
  1. Genetics
  2. Excretion
  3. Drug half-life
  4. Acid-base balance in the body

Question 2

A patient tells the nurse that he is experiencing gastrointestinal problems since he began taking a selective serotonin-reuptake inhibitor (SSRI) for depression. Which response by the nurse would be most appropriate?
 
  1. Try taking the medication will a full glass of water.
  2. Try taking the medication at bedtime.
  3. Try taking the medication with food.
  4. Try taking the medication at least an hour before eating.

[nathang24]

Answer to Question 1

Answer: 1
Explanation: Genetic differences influence the enzymatic process. Excretion is a result of the enzymatic process. The drug's half-life is influenced by the liver's enzymatic process, not the reverse. Acid-base balance is a renal function.

Answer to Question 2

Answer: 3
Explanation: SSRIs attaching to serotonin receptors in the digestive tract can cause digestive problems. Taking a small amount of food with the SSRI can alleviate these symptoms if they occur. Taking the medication on an empty stomach or taking it at bedtime will not help resolve the patient's symptoms. Although water soluble medications should be taken with water to assist in absorption, taking the medication with food will be more likely to alleviate GI distress.

[karen]

Thanks for the timely response, appreciate it

[ghepp]

TYSM