This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: What is the primary function of the P450 enzymes in the liver? What will be an ideal ... (Read 138 times)

renzo156

  • Hero Member
  • *****
  • Posts: 526
on: Jun 22, 2018
What is the primary function of the P450 enzymes in the liver?
 
  What will be an ideal response?

Question 2

Mathematically, how does one determine a drug's therapeutic index?
 
  What will be an ideal response?


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

Jane

  • Sr. Member
  • ****
  • Posts: 309
Reply #1 on: Jun 22, 2018
Answer to Question 1

To metabolize toxic chemicals introduced into the body into less active/toxic molecules or into more water-soluble (ionized) molecules that can be excreted more rapidly from the body via the kidneys (although sometimes the metabolites produced may actually become more active or toxic than the parent compound)

Answer to Question 2

First determine the dose that produces a specified or desired effect in 50 of a sample of individuals/animals (ED50) and the dose that produces lethality in 50 of a similar sample of individuals/animals (LD50), and then divide the LD50 by the ED50.


renzo156

  • Hero Member
  • *****
  • Posts: 526
Reply #2 on: Jun 22, 2018
Thank you


Jane

  • Sr. Member
  • ****
  • Posts: 309
Reply #3 on: Jun 22, 2018
No problem :)


« previous next »
 

Did you know?

There are over 65,000 known species of protozoa. About 10,000 species are parasitic.

Did you know?

According to animal studies, the typical American diet is damaging to the liver and may result in allergies, low energy, digestive problems, and a lack of ability to detoxify harmful substances.

Did you know?

Over time, chronic hepatitis B virus and hepatitis C virus infections can progress to advanced liver disease, liver failure, and hepatocellular carcinoma. Unlike other forms, more than 80% of hepatitis C infections become chronic and lead to liver disease. When combined with hepatitis B, hepatitis C now accounts for 75% percent of all cases of liver disease around the world. Liver failure caused by hepatitis C is now leading cause of liver transplants in the United States.

Did you know?

Cyanide works by making the human body unable to use oxygen.

Did you know?

The immune system needs 9.5 hours of sleep in total darkness to recharge completely.

Primary production increases with an increase in total phosphorus concentration. Primary production increases with an increase in total phosphorus concentration.
Illustration showing how the primary breast tumor metastasized through the lymphatic and blood vesse Illustration showing how the primary breast tumor metastasized through the lymphatic and blood vesse
Horizontal, sagittal, and coronal functional MRIs show areas of increased activity in the primary ... Horizontal, sagittal, and coronal functional MRIs show areas of increased activity in the primary ...
How to vertically stretch and compress a sinusoidal function (y=a*sin⁡b(x−c)+d) How to vertically stretch and compress a sinusoidal function (y=a*sin⁡b(x−c)+d)
From the following function, find the value of a, so that the AROC From the following function, find the value of a, so that the AROC
Consider the production function ( ) 0.5 0.5 Y = AK L . Suppose both saving rate (s) and the ... Consider the production function ( ) 0.5 0.5 Y = AK L . Suppose both saving rate (s) and the ...
Video: Mendel's Principles of Dominance, Segregation and Independent Assortment

For a complete list of videos, visit our video library