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Author Question: What is the primary function of the P450 enzymes in the liver? What will be an ideal ... (Read 107 times)

renzo156

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on: Jun 22, 2018
What is the primary function of the P450 enzymes in the liver?
 
  What will be an ideal response?

Question 2

Mathematically, how does one determine a drug's therapeutic index?
 
  What will be an ideal response?


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Jane

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Reply #1 on: Jun 22, 2018
Answer to Question 1

To metabolize toxic chemicals introduced into the body into less active/toxic molecules or into more water-soluble (ionized) molecules that can be excreted more rapidly from the body via the kidneys (although sometimes the metabolites produced may actually become more active or toxic than the parent compound)

Answer to Question 2

First determine the dose that produces a specified or desired effect in 50 of a sample of individuals/animals (ED50) and the dose that produces lethality in 50 of a similar sample of individuals/animals (LD50), and then divide the LD50 by the ED50.


renzo156

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Reply #2 on: Jun 22, 2018
Thank you


Jane

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Reply #3 on: Jun 22, 2018
No problem :)


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Did you know?

According to animal studies, the typical American diet is damaging to the liver and may result in allergies, low energy, digestive problems, and a lack of ability to detoxify harmful substances.

Did you know?

The human body's pharmacokinetics are quite varied. Our hair holds onto drugs longer than our urine, blood, or saliva. For example, alcohol can be detected in the hair for up to 90 days after it was consumed. The same is true for marijuana, cocaine, ecstasy, heroin, methamphetamine, and nicotine.

Did you know?

Never take aspirin without food because it is likely to irritate your stomach. Never give aspirin to children under age 12. Overdoses of aspirin have the potential to cause deafness.

Did you know?

Oliver Wendell Holmes is credited with introducing the words "anesthesia" and "anesthetic" into the English language in 1846.

Did you know?

The Centers for Disease Control and Prevention has released reports detailing the deaths of infants (younger than 1 year of age) who died after being given cold and cough medications. This underscores the importance of educating parents that children younger than 2 years of age should never be given over-the-counter cold and cough medications without consulting their physicians.

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