How do protease inhibitor (PI) drugs prevent viral replication?
a. They are counterfeit bases that prevent reverse transcriptase from synthesizing the DNA needed for viral replication.
b. They inactivate the enzyme that allows the viral genetic material to be integrated into the human host's cellular DNA.
c. They prevent the production of proteins needed for viral particles to leave the cell and infect other cells.
d. They prevent initial infection by blocking the receptor the virus uses to enter target cells.
Question 2
A patient who has been taking indinavir (Crixivan) for a year has just been told that the organism is now resistant to this drug. The patient expresses worry to you that this means the disease will now progress to acquired immunodeficiency syndrome (AIDS)
and death will soon follow. What is your best response?
a. Your health care provider can change this drug to the intravenous form, which prevents viral replication even in HIV that has developed drug resistance.
b. Although the HIV is now resistant to this drug, other antiretroviral drugs are likely to be effective in controlling your disease.
c. The HIV easily becomes drug resistant. That is why the drug combinations are switched so often.
d. That is a possibility because these drugs do not kill the virus. It is best to be prepared.
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