Answer to Question 1
Correct Answer: 1,2
Rationale: Drug plateaus occur with medications because all the receptors for the drug are occupied; the drug has brought 100 relief to the patient. A drug plateau is not related to efficacy of the drug. When a drug has reached its plateau, giving additional amounts will not result in an increased therapeutic effect.
Answer to Question 2
Correct Answer: 4
Rationale: Once the plateau of a drug has been reached, increasing the dose may produce adverse effects. Once the plateau of a drug has been reached, increased doses will not provide added therapeutic benefit, such as more pain relief. Tolerance may occur, but is not the primary issue here.