Answer to Question 1
1, 3, 5
Rationale 1:Sucralfate (Carafate) needs to be taken four times a day.
Rationale 2:The medication works by producing a thick, gel-like substance that coats the ulcer.
Rationale 3:Sucralfate (Carafate) with the coating will protect the ulcer against further erosion and promote healing.
Rationale 4:The medication is not absorbed by the GI tract.
Rationale 5:The medication may cause constipation.
Global Rationale: Sucralfate (Carafate) consists of sucrose (a sugar) plus aluminum hydroxide (an antacid). The drug produces a thick, gel-like substance that coats the ulcer, protecting it against further erosion and promoting healing. Very little of the drug is absorbed from the GI tract. Other than constipation, adverse effects are minimal. A major disadvantage of sucralfate is that it must be taken four times a day.
Answer to Question 2
3
Rationale 1:Amoxicillin (Amoxil) is an antibiotic. Metoclopramide (Reglan) is a miscellaneous drug used for peptic ulcer disease.
Rationale 2:Metronidazole (Flagyl) is a preferred antibiotic. Ranitidine (Zantac) is an H2-receptor blocker.
Rationale 3:Clarithromycin (Biaxin) and amoxicillin (Amoxil) are the preferred antibiotic combination.
Rationale 4:Tetracycline (Sumycin) is a preferred antibiotic. Pantoprazole (Protonix) is a proton-pump inhibitor.
Global Rationale: Two or more antibiotics are given concurrently to increase the effectiveness of therapy and to lower the potential for bacterial resistance. Clarithromycin (Biaxin) and amoxicillin (Amoxil)are the preferred drug combination.