Answer to Question 1
1
Rationale 1: Levodopa can cross the bloodbrain barrier, but dopamine cannot. Levodopa administration leads directly to dopamine synthesis.
Rationale 2: Levodopa does not have fewer side effects.
Rationale 3: There is no risk for addiction from either substance.
Rationale 4: Route of administration is not a factor.
Global Rationale: Levodopa can cross the bloodbrain barrier, but dopamine cannot. Levodopa administration leads directly to dopamine synthesis. Levodopa does not have fewer side effects. There is no risk for addiction from either substance. Route of administration is not a factor.
Answer to Question 2
2
Rationale 1: Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and do not affect histamine.
Rationale 2: Histamine dilates blood vessels causing capillaries to become more permeable. The affected area may become congested with blood.
Rationale 3: Histamine dilates, not constricts, vessels, causing capillaries to become more permeable.
Rationale 4: Histamine is primarily stored in mast cells, not phagocyte cells.
Global Rationale: Histamine dilates blood vessels causing capillaries to become more permeable. The affected area may become congested with blood. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and do not affect histamine. Histamine dilates, not constricts, vessels, causing capillaries to become more permeable. Histamine is primarily stored in mast cells, not phagocyte cells.