Answer to Question 1
1,2
Rationale 1: Unconsciousness after the first dose of prazosin (Minipress) is typically due to severe hypotension. Normal saline can be used as a volume expander.
Rationale 2: Unconsciousness after the first dose of prazosin (Minipress) is typically due to severe hypotension. Treatment with a vasopressor such as dobutamine may be indicated.
Rationale 3: Atenolol (Tenormin) is an adrenergic blocker and would exacerbate the problem.
Rationale 4: Carvedilol (Coreg) is an adrenergic blocker and would exacerbate the problem.
Rationale 5: Propranolol (Inderal) is an adrenergic blocker and would exacerbate the problem.
Global Rationale: Unconsciousness after the first dose of prazosin (Minipress) is typically due to severe hypotension. Normal saline can be used as a volume expander. Treatment with a vasopressor such as dobutamine may be indicated. Atenolol (Tenormin), carvedilol (Coreg), and propranolol (Inderal) are adrenergic blockers and would exacerbate the problem.
Answer to Question 2
3
Rationale 1: Grapefruit juice inhibits the metabolism of the calcium channel blockers.
Rationale 2: Hydrochlorothiazide (Microzide) is a potassium-excreting diuretic, and potassium supplementation is often necessary.
Rationale 3: Taking hydrochlorothiazide (Microzide) early in the day will help prevent nocturia.
Rationale 4: Development of a cough occurs with ACE inhibitors, not diuretics.
Global Rationale: Taking hydrochlorothiazide (Microzide) early in the day will help prevent nocturia. Grapefruit juice inhibits the metabolism of the calcium channel blockers. Hydrochlorothiazide (Microzide) is a potassium-excreting diuretic, and potassium supplementation is often necessary. Development of a cough occurs with ACE inhibitors, not diuretics.