Author Question: Literature review reveals that a new drug has a median lethal dose of 10 and a median effective dose ... (Read 146 times)

jc611 · **on:** Jul 23, 2018

Literature review reveals that a new drug has a median lethal dose of 10 and a median effective dose of 5. The nurse determines that an error in which _____ times the correct dose is given could be lethal. Standard Text: Record your answer rounding to the nearest whole number.

Fill in the blank(s) with correct word

Question 2

The nurse is reviewing the medication administration record for a group of patients and recognizes that which agents have nonspecific cellular responses? Note: Credit will be given only if all correct choices and no incorrect choices are selected. Standard Text: Select all that apply.

1. Ethyl alcohol
2. General anesthetics
3. Osmotic diuretics
4. Calcium channel blockers
5. Alpha-adrenergic antihypertensives

kxciann · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

2
Rationale: x = 10/5; solving for x, the therapeutic index would be 2. This means it would only take an error in magnitude of approximately 2 times the average dose to be lethal.
Global Rationale: x = 10/5; solving for x, the therapeutic index would be 2. This means it would only take an error in magnitude of approximately 2 times the average dose to be lethal.

Answer to Question 2

1,2,3
Rationale 1: Ethyl alcohol is an example of an agent that acts by nonspecific mechanisms, independently of cellular receptors.
Rationale 2: General anesthetics are an example of agents that act by nonspecific mechanisms, independently of cellular receptors.
Rationale 3: Osmotic diuretics are an example of agents that act by nonspecific mechanisms, independently of cellular receptors.
Rationale 4: Calcium channel blockers have a specific mechanism of action.
Rationale 5: Alpha-adrenergic antihypertensives have a specific mechanism of action.
Global Rationale: Ethyl alcohol is an example of an agent that acts by nonspecific mechanisms, independently of cellular receptors. General anesthetics are an example of agents that act by nonspecific mechanisms, independently of cellular receptors. Osmotic diuretics are an example of agents that act by nonspecific mechanisms, independently of cellular receptors. Calcium channel blockers have a specific mechanism of action. Alpha-adrenergic antihypertensives have a specific mechanism of action.