Answer to Question 1
ANS: B
Orlistat may cause hypothyroidism in patients taking levothyroxine; these two drugs should be administered at least 4 hours apart. The vitamin K deficiency that can occur with orlistat may compound the effects of warfarin, so coagulation should be monitored; it is more likely that the warfarin dose would need to be reduced. The patient may still consume foods containing fat, as long as fat accounts for about 30 of the total intake. Orlistat should be taken with food.
Answer to Question 2
ANS: C
Because orlistat reduces fat absorption, stools often are fatty or oily, and fecal incontinence can occur. Bulk-forming laxatives can help with this side effect. For orlistat to be effective, patients still need to adopt a reduced-calorie diet with a 30 fat content. Patients should take fat-soluble vitamin supplements to replace those lost in stools. Taking the drug more often does not increase weight loss.