Answer to Question 1
Correct Answer: 2
Rationale 1: Ritonavir is not the preferred drug to be used in combination with zidovudine for perinatal transmission prevention.
Rationale 2: The preferred drug to be used in combination with zidovudine for perinatal transmission prevention is lamivudine.
Rationale 3: Tenofovir is not the preferred drug to be used in combination with zidovudine for perinatal transmission prevention.
Rationale 4: Didanosine is not the preferred drug to be used in combination with zidovudine for perinatal transmission prevention.
Global Rationale: Recommended protocols for the pregnant woman include two NRTIs (zidovudine and lamivudine) with either an NNRTI (nevirapine) or a PI (lopinavir boosted with ritonavir). The specific regimen is adjusted based on resistance testing.
Answer to Question 2
Correct Answer: 2
Rationale 1: PEP should be started much sooner than 2 weeks after exposure.
Rationale 2: PEP should be started 2436 hours after exposure to be most successful.
Rationale 3: PEP should be started sooner than 3648 hours after exposure.
Rationale 4: PEP should be started sooner than 1 week after exposure.
Global Rationale: For prevention to be most successful, PEP should be started within 24 to 36 hours after exposure to a source person who is known to be HIV positive.
Early in the twentieth century, when malnutrition was common, companies such as this one advertised
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Example of “drug facts” labeling on the box of an OTC drug.
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Use of squid giant axons for studies of neural transmission