Author Question: The preferred drug to be used in combination with zidovudine for perinatal transmission prevention ... (Read 100 times)

Brittanyd9008 · **on:** Jul 23, 2018

The preferred drug to be used in combination with zidovudine for perinatal transmission prevention is:

1. ritonavir.
2. lamivudine.
3. tenofovir.
4. didanosine.

Question 2

Postexposure prophylaxis (PEP) for occupational HIV exposure should be started within what time period after exposure to be most successful?

1. 2 weeks
2. 2436 hours
3. 3648 hours
4. 1 week

Dnite · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 2
Rationale 1: Ritonavir is not the preferred drug to be used in combination with zidovudine for perinatal transmission prevention.
Rationale 2: The preferred drug to be used in combination with zidovudine for perinatal transmission prevention is lamivudine.
Rationale 3: Tenofovir is not the preferred drug to be used in combination with zidovudine for perinatal transmission prevention.
Rationale 4: Didanosine is not the preferred drug to be used in combination with zidovudine for perinatal transmission prevention.
Global Rationale: Recommended protocols for the pregnant woman include two NRTIs (zidovudine and lamivudine) with either an NNRTI (nevirapine) or a PI (lopinavir boosted with ritonavir). The specific regimen is adjusted based on resistance testing.

Answer to Question 2

Correct Answer: 2
Rationale 1: PEP should be started much sooner than 2 weeks after exposure.
Rationale 2: PEP should be started 2436 hours after exposure to be most successful.
Rationale 3: PEP should be started sooner than 3648 hours after exposure.
Rationale 4: PEP should be started sooner than 1 week after exposure.
Global Rationale: For prevention to be most successful, PEP should be started within 24 to 36 hours after exposure to a source person who is known to be HIV positive.