Salicylates primarily inhibit the synthesis of which substance? ...

[washai]

Salicylates primarily inhibit the synthesis of which substance?
 
  1. Pyrogens
  2. Superoxide radicals
  3. Histamines
  4. Prostaglandins

Question 2

Aspirin has which adverse effect on the gastrointestinal mucosa?
 
  1. Aspirin causes direct cellular injury as it is absorbed across the stomach mucosa.
  2. Because all aspirin products have an enteric coating, there is no topical damage to the stomach.
  3. After aspirin is systemically absorbed, it inhibits COX-2.
  4. Aspirin enhances the effect of prostaglandins' protective function to the GI mucosa.

[gstein359]

Answer to Question 1

Correct Answer: 4
Rationale 1: Pyrogens are substances that increase body temperature. Salicylates do not act directly on the pyrogens.
Rationale 2: Superoxide radicals are blocked by ibuprofen.
Rationale 3: Histamines are an important chemical substance released during the inflammatory process and are not blocked by salicylates.
Rationale 4: Aspirin blocks the synthesis of prostaglandins by inhibiting the enzyme cyclooxygenase (COX).
Global Rationale: All NSAIDs act by inhibiting the synthesis of prostaglandins which are local hormones found in virtually every tissue. Prostaglandins have many diverse functions depending on their location. Pyrogens are substances that increase body temperature. Salicylates do not act directly on the pyrogens. Superoxide radicals are blocked by ibuprofen. Histamines are an important chemical substance released during the inflammatory process and are not blocked by salicylates.

Answer to Question 2

Correct Answer: 1
Rationale 1: Aspirin causes topical damage to the stomach as it crosses the mucosa. This direct cellular injury can result in GI bleeding.
Rationale 2: Not all aspirin products are enteric-coated.
Rationale 3: Aspirin inhibits COX-1 once it is systemically absorbed; it depletes the GI mucosa of prostaglandin.
Rationale 4: Aspirin depletes the GI mucosa of prostaglandins.
Global Rationale: As aspirin is absorbed across the stomach mucosa, it causes direct cellular injury. This topical damage to the stomach may be lessened by the use of enteric-coated formulations. After aspirin is absorbed systemically, it inhibits COX-1 and depletes the GI mucosa of prostaglandins which normally provide a protective function by directing the secretion of mucus and bicarbonate and promoting cellular repair of mucosal damage. Not all aspirin products are enteric-coated.

[washai]

Both answers were spot on, thank you once again

[gstein359]

Great! Please up vote