When checking on the potential interactions of two drugs being ...

[rlane42]

When checking on the potential interactions of two drugs being administered at the same time, the nurse recognizes which principle?
 
  1. Drugdrug interactions are more serious than drugfood interactions.
  2. All drugs will have some type of interaction.
  3. Drug interactions should always be avoided.
  4. Some drug interactions can produce therapeutic effects.

Question 2

A client is receiving an antiviral drug that is a substrate of the CYP3A4 enzyme system. When a drug that is an inhibitor of the 3A4 system is added to the client's regimen, the nurse should assess the client for which result?
 
  1. Toxicity of the antiviral drug
  2. No change in viral-related symptoms
  3. A decrease in the antiviral drug side effects
  4. An increase in viral load

[miss_1456@hotmail.com]

Answer to Question 1

Correct Answer: 4
Rationale 1: Drugfood interactions can be just as serious as drugdrug interactions.
Rationale 2: Although most drugs do have some type of interaction, it is possible that a drug might not have any.
Rationale 3: Therapeutic drug interactions do not need to be avoided.
Rationale 4: The combination of some drugs can produce a synergistic or additive effect, which often are therapeutic in nature.
Global Rationale: The combination of some drugs can produce a synergistic or additive effect, which often are therapeutic in nature. Drugfood interactions can be just as serious as drugdrug interactions. Although most drugs do have some type of interaction, it is possible that a drug might not have any. Therapeutic drug interactions do not need to be avoided.

Answer to Question 2

Correct Answer: 1
Rationale 1: The drug inhibitor will interact with the antiviral drug and inhibit metabolism of it, resulting in accumulation of the drug with possible toxic effects.
Rationale 2: A change in viral-related symptoms could occur, since the level of antiviral drug is increased.
Rationale 3: An increase in side effects of the antiviral drug could occur, since more of the drug will remain in the bloodstream.
Rationale 4: Since the serum level of the antiviral drug will be elevated, the viral load might decrease, not increase.
Global Rationale: The drug inhibitor will interact with the antiviral drug and inhibit metabolism of it, resulting in accumulation of the drug with possible toxic effects. A change in viral-related symptoms could occur, since the level of antiviral drug is increased. An increase in side effects of the antiviral drug could occur, since more of the drug will remain in the bloodstream. Since the serum level of the antiviral drug will be elevated, the viral load might decrease, not increase.

[rlane42]

Thank you!

[miss_1456@hotmail.com]

Always glad to help...