Author Question: Ketoconazole (Sporanox) is used as an alternative to amphotericin B for less severe systemic ... (Read 28 times)

lb_gilbert · **on:** Jul 23, 2018

Ketoconazole (Sporanox) is used as an alternative to amphotericin B for less severe systemic mycosis. The primary reason (or reasons) for choosing ketoconazole is which of the following? (Select all that apply.)

a. Ketoconazole can be given orally.
b. Ketoconazole can be used safely in patients with hepatic dysfunction.
c. Ketoconazole can be given once per week rather than daily.
d. It is the prescriber's choice because the drugs are comparable.
e. Ketoconazole is safer.

Question 2

The nurse is monitoring a patient who is having her sixth child. The patient has gone beyond term, and labor is being induced with oxytocin (Pitocin). The nurse understands that this patient is at risk for

a. hemorrhage.
b. placental insufficiency.
c. uterine rupture.
d. water intoxication.

Briannahope · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

A, E
Ketoconazole is given instead of amphotericin B because it is safer and can be administered orally. Amphotericin B is administered intravenously.
Ketoconazole is hepatotoxic. It is given daily.
The drugs are comparable in effect but not in safety.

Answer to Question 2

C
Induction of labor in women of high parity (five or more pregnancies) carries a high risk of ute-rine rupture, and oxytocin should be used with great caution.
Oxytocin poses no apparent risk of hemorrhage or placental insufficiency.
The patient would be at risk for water intoxication if high doses of oxytocin were being adminis-tered.