Author Question: A nursing student asks a nurse how cancer cells become resistant to methotrexate Rheumatrex. The ... (Read 32 times)

erika · **on:** Jul 23, 2018

A nursing student asks a nurse how cancer cells become resistant to methotrexate Rheumatrex. The nurse is correct to respond by saying that cancer cells acquire resistance to methotrexate by:

a. reduced production of transporter that pumps methotrexate out of cells.
b. reduced synthesis of dihydrofolate reduc-tase.
c. reduced uptake of methotrexate into cells.
d. increased ability to convert the drug to a polyglutamated form.

Question 2

A patient who has urinary bladder cancer will begin receiving the chemotherapeutic agent valrubicin Valstar. What will the nurse do when administering this drug?

a. Administer the drug intravenously using a large bore needle and tubing.
b. Ensure that the tubing used to administer the drug does not contain polyvinyl chlo-ride.
c. Monitor the patient closely for a variety of systemic drug adverse effects.
d. Use a normal saline or sterile water diluent to dilute the medication.

Question 3

A 43-year-old patient with a strong family history of breast cancer considers taking tamoxifen Nolvadex for cancer prevention. Which assessment finding is a possible contraindication?

a. History of deep vein thrombosis (DVT)
b. History of osteoporosis
c. Hyperlipidemia
d. Prior hysterectomy

wergv · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

This is great. Thanks

Answer to Question 2

Many thanks to you.

Answer to Question 3

A
The patient's age and DVT history place her at risk for thrombosis. Tamoxifen would not be in-dicated for this patient. A prior hysterectomy, osteoporosis, and hyperlipidemia are not contrain-dications to tamoxifen.