Protein kinases are enzymes that transfer the terminal phosphate from ATP to an amino acid residue on the target protein. Many are located on the plasma membrane as integral membrane proteins or peripheral membrane proteins. What purpose may be served by their plasma membrane localization?
A) ATP is more abundant near the plasma membrane.
B) They can more readily encounter and phosphorylate other membrane proteins.
C) Membrane localization lowers the activation energy of the phosphorylation reaction.
D) They flip back and forth across the membrane to access target proteins on either side.
E) They require phospholipids as a cofactor.
First-pass effect: (a) drugs are absorbed; (b) drugs enter hepatic portal circulation and go directl
Localization of Fos Protein
Levels of protein structure: Quaternary structure
Mass spectrometry for identifying an unknown protein isolated from a 2D gel
Gene-transfer processes in bacteria