What drugs used to treat rheumatoid arthritis are contraindicated ...

[TVarnum]

What drugs used to treat rheumatoid arthritis are contraindicated in a patient who has a history of toxic levels of heavy metals?
 
  A) Gold salts
  B) COX-2 inhibitors
  C) Propionic acids
  D) Fenamates

Question 2

The nurse is teaching a class for newly hired cardiac care nurses and is discussing dronedarone (Multaq). What statement, if made by the nurse, is accurate? (Select all that apply.)
 
  A) Dronedarone has properties of all four classes of antiarrhythmics.
  B) Dronedarone reduces the risk of hospitalization in patients in atrial fibrillation.
  C) Dronedarone has many drugdrug interactions that need to be reviewed.
  D) It is an oral drug taken once a day.
  E) Common adverse effects of dronedarone include ventricular arrhythmias.

[peilian]

Answer to Question 1

A
Feedback:
Gold salts can be extremely toxic and are contraindicated in the presence of any known allergy to gold, severe diabetes mellitus, congestive heart failure, severe debilitation, renal or hepatic impairment, hypertension, blood dyscrasias, recent radiation treatment, history of toxic levels of heavy metals, and pregnancy or lactation. COX-2 inhibitors, propionic acids, and fenamates have no contraindications related to prior toxic levels of heavy metals.

Answer to Question 2

A, B, C
Feedback:
Dronedarone has properties of all four classes of antiarrhythmics and the mechanism by which it helps suppress atrial arrhythmias is not fully understood. It is used to reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation or flutter who have risk factors for cardiovascular disease and who are in sinus rhythm or are scheduled to be converted to sinus rhythm. The drug is taken orally twice a day. Many drugdrug interactions have been associated with the drug and this situation should always be reviewed before starting or stopping any drugs while on this drug. Grapefruit juice should not be consumed while taking this drug. The most common adverse effects seen with dronedarone are heart failure, prolonged QT interval, nausea, diarrhea, and rash. It should never be used during pregnancy because it has been associated with fetal abnormalities.

[TVarnum]

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[peilian]

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