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Author Question: A patient's current medical condition is suggestive of impaired erythropoiesis. Which of the ... (Read 53 times)

Starlight

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on: Jul 23, 2018
A patient's current medical condition is suggestive of impaired erythropoiesis. Which of the following laboratory studies would be most clinically relevant in diagnosing this health problem?
 
  A) White blood cell count with differential
  B) RBC, hemoglobin, and hematocrit
  C) INR and aPTT
  D) d-dimer and C-reactive protein

Question 2

A patient suffers from insomnia and is prescribed flurazepam. This medication has a longer half-life than 24 hours. Which of the following contributes to the long half-life of this medication and other benzodiazepines?
 
  A) Metabolism by cytochrome P450
  B) Presence of active metabolites
  C) Excretion by the renal system
  D) Movement of calcium in the cell


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wilsonbho

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Reply #1 on: Jul 23, 2018
Answer to Question 1

B
Feedback:
Parameters used to measure erythropoiesis include RBC count, hemoglobin concentration and hematocrit, and mean corpuscular volume. Tests related to immune function, hemostasis, and inflammation are not used to diagnose erythropoiesis.

Answer to Question 2

B
Feedback:
Benzodiazepines differ mainly in their plasma half-lives, production of active metabolites, and clinical uses. Drugs with half-lives longer than 24 hours form active metabolites that also have long half-lives and tend to accumulate, especially in older adults and people with impaired liver function. Flurazepam is not metabolized by cytochrome P450 . Flurazepam is excreted in the renal system but does not contribute to the effect on the half-life. Flurazepam does not contribute to movement of calcium in the cell.


Starlight

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Reply #2 on: Jul 23, 2018
Both answers were spot on, thank you once again


wilsonbho

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Reply #3 on: Jul 23, 2018
Great! Please up vote :D


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