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Opium has influenced much of the world's most popular literature. The following authors were all opium users, of varying degrees: Lewis Carroll, Charles, Dickens, Arthur Conan Doyle, and Oscar Wilde.
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Acetaminophen (Tylenol) in overdose can seriously damage the liver. It should never be taken by people who use alcohol heavily; it can result in severe liver damage and even a condition requiring a liver transplant.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.