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Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.