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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.
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More than 30% of American adults, and about 12% of children utilize health care approaches that were developed outside of conventional medicine.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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The FDA recognizes 118 routes of administration.